How Brexit was made in England

Revolution in the valley - the insanely great story of how the Mac was made

How the biotin–streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer

The interaction between SA (streptavidin) and biotin is one of the strongest non-covalent interactions in Nature. SA is a widely used tool and a paradigm for protein-ligand interactions. We previously developed a SA mutant, termed Tr (traptavidin), possessing a 10-fold lower off-rate for biotin, with increased mechanical and thermal stability. In the present study, we determined the crystal str...

How Infectious Was #Deflategate?

On Monday January 19, 2015 a story broke that the National Football League (NFL) had started an investigation into whether the New England Patriots deliberately deflated the footballs they used during their championship win over the Indianapolis Colts. Like an infectious disease, discussion regarding Deflategate grew rapidly on social media sites in the hours and days after the release of the s...

How Was Your Day?

We describe a ‘How was your day?’ (HWYD) Companion whose purpose is to establish a comforting and supportive relationship with a user via a conversation on a variety of work-related topics. The system has several fairly novel features aimed at increasing the naturalness of the interaction: a rapid ‘short loop’ response primed by the results of acoustic emotion analysis, and an ‘interruption man...

How Was F6 Factored?

In 1880 at the age of 82 Fortuné Landry factored the 20 digit number F6 = 264 + 1 . How did he do it? Landry himself never described how he factored F6 ; however, he did leave enough clues in his work and letters to provide some indication of the ideas with which he was working. In this paper we present a likely reconstruction of Landry's technique.